From Madrid and the south of Spain.
Follow the A6 to Benavente. The take the A66 in the direction of Leon. Then take the AP66 to Oviedo, next follow the N634 direction Santander, to Arriondas, then the N625 win take you to Cangas de Onís.

From Galicia.
The best option is to follow thw N-632 from Ribadeo to Oviedo.

From Cataluña and Valle del Ebro.
Take the Zaragoza-Bilbao motorway. When in Bilbao, follow the A8/E70 to Santander. Then take the A67 to Torrelavega. Then take the N634/E70 till Ribadesella, turning off at junction 326, following the signs for Arriondas, next follow the N-625 to Cangas de Onis.

Once in Cangas de Onis, take the national road direction Arenas de Cabrales, on reaching Corao, after about 5 km, look out for a sign, on your left, for Labra and Nueva. Take the turn, 200 m. on your left you will see the sign for Corain, go up the hill and carry on the narrow lane right to the end and you will come to Casa Liron.